“…approximately 40% of the variance in personality could be attributed to genetic factors…”


For extraversion, we found a significant locus on 12q23.3 within WSCD2. This locus has been implicated in a GWAS of temperament in bipolar disorder11 and in a linkage analysis12, suggesting that 12q harbors important alleles for temperament and personality. Another SNP significantly associated with extraversion is near PCDH15, which encodes a member of the cadherin superfamily important for calcium-dependent cell–cell adhesion.


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