“The goal is to get less wrong over time.” This concept is fundamental — whatever we know now is only our best approximation of the truth. We can never presume to have everything right.
“By default, we’re biased to try and find extreme results,”
“Science is great, but it’s low-yield. Most experiments fail. That doesn’t mean the challenge isn’t worth it, but we can’t expect every dollar to turn a positive result. Most of the things you try don’t work out — that’s just the nature of the process.”
Human fallibilities send the scientific process hurtling in fits, starts and misdirections instead of in a straight line from question to truth.