The Cortex

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At first glance, the architecture of the cortex seems bizarre. Long-range connectivity in the cortex follows the basic rule that sensory input (i.e., the feed-forward stream) terminates in the middle cortical layers, whereas information from other parts of the cortex (i.e., the feedback stream) tends to project to the outer layers [9,10,11,12,13] (Figure 1). This also applies to projections from the thalamus, a structure that serves as both a gateway for feed-forward sensory information to the cortex and as a hub for feedback interactions between cortical regions

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