“Intense stress promotes PTSD, which has been associated with exaggerated startle and deficient sensorimotor gating.”

A deficit in information-filtering mechanisms such as sensori-motor gating is presumed to contribute to cognitive and affective impairment in neuropsychiatric disorders like schizophrenia and post-traumatic stress disorder (PTSD). These deficits can be quantified using prepulse inhibition (PPI), a paradigm in which startle responses are inhibited by the presentation of a weak pre-stimulus immediately before the startling event. PPI deficits are observed in both illnesses, and stress is thought to exacerbate or precipitate symptomatology in them, possibly through a long-lasting hypersensitivity to perceived environmental threat

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