“Gambling disorder has point prevalence of around 0.5–2% across the globe, and is highly comorbid with other mental health disorders.”

  • Neuroimaging data suggest structural and functional abnormalities of networks involved in reward processing and top-down control.
  • Gambling disorder shows 50–60% heritability and it is likely that various neurochemical systems are implicated in the pathophysiology (including dopaminergic, glutamatergic, serotonergic, noradrenergic, and opioidergic).
  • Elevated rates of certain personality traits (e.g. negative urgency, disinhibition), and personality disorders, are found.

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